![]() More broadly, smart RT biomaterials may include functionalized nanoparticles that can be activated to boost radiotherapy efficacy. ![]() Such smart biomaterials include next generation fiducial markers, brachytherapy spacers, and balloon applicators, designed to respond to stimulus and perform additional desirable functions like controlled delivery of therapy-enhancing payloads directly into the tumor sub-volume, while minimizing normal tissue toxicities. Recent studies have proposed that the inert biomaterials could be upgraded to ‘smart’ RT biomaterials, designed to do more than one function. The single function of these RT biomaterials is to ensure geometric accuracy during treatment. Patients undergoing image-guided radiotherapy or brachytherapy routinely have inert radiotherapy (RT) biomaterials implanted into their tumors. ![]() Radiotherapy is a crucial component of cancer care, employed in the treatment of over 50% of cancer patients.
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